About DIP

The Database of Interacting Proteins (DIP) archives and evaluates experimentally determined interactions between proteins.

The interactions in DIP are culled from peer-reviewed literature and are manually entered into the database by expert curators. Direct data submission by researchers, with curator oversight, helps streamline this process. In both cases, the resulting high-quality curation conforms to the Proteomic Standards Initiative's Molecular Interaction (PSI-MI) format, allowing simplified data mining and smooth exchange of data between interaction databases.

DIP is a member of the International Molecular-interaction Exchange Consortium (IMEx), a group of the major public providers of interaction data. Other participating databases include IntAct, MINT, MPact, and BioGRID. The databases of IMEx work together to prevent duplications of curation effort, collecting data from non-overlapping sources and sharing the curated interaction data.

In addition to manual curation, interactions in DIP undergo computational evaluation. The evaluation algorithms judge whether a reported interaction is likely to be biologically relevant by comparing its properties to those of the most reliable, core subset of DIP interactions. The results of evaluation are displayed on the interaction's information page.

For more about DIP, try the following links:

News Announcements of the latest updates to DIP
Statistics A breakdown of database contents and site use
Articles Links to publications describing DIP in greater detail
User Guide About the website and how to use DIP