The Database of Interacting Proteins (DIP) archives and evaluates experimentally
determined interactions between proteins.
The interactions in DIP are culled
from peer-reviewed literature and are manually entered into the database by expert
curators. Direct data submission
by researchers, with
curator oversight, helps streamline this process. In both cases, the resulting
high-quality curation conforms to the Proteomic
's Molecular Interaction (PSI-MI) format, allowing simplified
data mining and smooth exchange of data between interaction databases.
DIP is a member of the International Molecular-interaction Exchange Consortium
(IMEx), a group of the major public providers of
interaction data. Other participating databases include
BioGRID. The databases of IMEx work together
to prevent duplications of curation effort, collecting data from non-overlapping
sources and sharing the curated interaction data.
In addition to manual curation, interactions in DIP undergo computational evaluation.
The evaluation algorithms judge whether a reported interaction is likely to be biologically
relevant by comparing its properties to those of the most reliable, core subset
of DIP interactions. The results of evaluation are displayed on the interaction's
For more about DIP, try the following links:
||Announcements of the latest updates to DIP
||A breakdown of database contents and site use
||Links to publications describing DIP in greater detail
||About the website and how to use DIP